Disruption of the 11-cis-Retinol Dehydrogenase Gene Leads to Accumulation of cis-Retinols and cis-Retinyl Esters

To elucidate the possible role of 11-cis-retinol dehydrogenase in the visual cycle and/or 9-cis-retinoic acid biosynthesis, we generated mice carrying a targeted disruption of the 11-cis-retinol dehydrogenase gene. Homozygous 11-cis-retinol dehydrogenase mutants developed normally, including their r...

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Detalhes bibliográficos
Main Authors: Driessen, Carola A. G. G., Winkens, Huub J., Hoffmann, Kirstin, Kuhlmann, Leonoor D., Janssen, Bert P. M., Van Vugt, Anke H. M., Van Hooser, J. Preston, Wieringa, B. E., Deutman, August F., Palczewski, Krzysztof, Ruether, Klaus, Janssen, Jacques J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC85795/
https://ncbi.nlm.nih.gov/pubmed/10825191
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