Altered Activity, Social Behavior, and Spatial Memory in Mice Lacking the NTAN1p Amidase and the Asparagine Branch of the N-End Rule Pathway

The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. N-terminal asparagine and glutamine are tertiary destabilizing residues, in that they are enzymatically deamidated to yield secondary destabilizing residues aspartate and glutamate, which are conjuga...

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Autores principales: Kwon, Yong Tae, Balogh, Seth A., Davydov, Ilia V., Kashina, Anna S., Yoon, Jeong Kyo, Xie, Youming, Gaur, Arti, Hyde, Lynn, Denenberg, Victor H., Varshavsky, Alexander
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2000
Materias:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC85783/
https://ncbi.nlm.nih.gov/pubmed/10805755
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