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Analysis of ku80-Mutant Mice and Cells with Deficient Levels of p53

Absence of Ku80 results in increased sensitivity to ionizing radiation, defective lymphocyte development, early onset of an age-related phenotype, and premature replicative senescence. Here we investigate the role of p53 on the phenotype of ku80-mutant mice and cells. Reducing levels of p53 increase...

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Bibliografiske detaljer
Main Authors: Lim, Dae-Sik, Vogel, Hannes, Willerford, Dennis M., Sands, Arthur T., Platt, Kenneth A., Hasty, Paul
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC85695/
https://ncbi.nlm.nih.gov/pubmed/10805721
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