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Somatic mRNA Turnover Mutants Implicate Tristetraprolin in the Interleukin-3 mRNA Degradation Pathway

Control of mRNA stability is critical for expression of short-lived transcripts from cytokines and proto-oncogenes. Regulation involves an AU-rich element (ARE) in the 3′ untranslated region (3′UTR) and cognate trans-acting factors thought to promote either degradation or stabilization of the mRNA....

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Published in:Mol Cell Biol
Main Authors: Stoecklin, Georg, Ming, Xiu-Fen, Looser, Renate, Moroni, Christoph
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2000
Subjects:
Gene Expression
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85689/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10805719/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.11.3753-3763.2000
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