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Inactivation of p53 by Human T-Cell Lymphotropic Virus Type 1 Tax Requires Activation of the NF-κB Pathway and Is Dependent on p53 Phosphorylation

p53 plays a key role in guarding cells against DNA damage and transformation. We previously demonstrated that the human T-cell lymphotropic virus type 1 (HTLV-1) Tax can inactivate p53 transactivation function in lymphocytes. The present study demonstrates that in T cells, Tax-induced p53 inactivati...

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Publicado no:Mol Cell Biol
Principais autores: Pise-Masison, Cynthia A., Mahieux, Renaud, Jiang, Hua, Ashcroft, Margaret, Radonovich, Michael, Duvall, Janet, Guillerm, Claire, Brady, John N.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2000
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85630/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10779327/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.10.3377-3386.2000
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