Methylation of the Cyclin A1 Promoter Correlates with Gene Silencing in Somatic Cell Lines, while Tissue-Specific Expression of Cyclin A1 Is Methylation Independent

Gene expression in mammalian organisms is regulated at multiple levels, including DNA accessibility for transcription factors and chromatin structure. Methylation of CpG dinucleotides is thought to be involved in imprinting and in the pathogenesis of cancer. However, the relevance of methylation for...

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Bibliographic Details
Main Authors: Müller, Carsten, Readhead, Carol, Diederichs, Sven, Idos, Gregory, Yang, Rong, Tidow, Nicola, Serve, Hubert, Berdel, Wolfgang E., Koeffler, H. Phillip
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Transcriptional Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC85625/
https://ncbi.nlm.nih.gov/pubmed/10757815
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