Suppression of Nonsense Mutations in Cell Culture and Mice by Multimerized Suppressor tRNA Genes

We demonstrate here the first experimental suppression of a premature termination codon in vivo by using an ochre suppressor tRNA acting in an intact mouse. Multicopy tRNA expression plasmids were directly injected into skeletal muscle and into the hearts of transgenic mice carrying a reporter gene...

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Detaylı Bibliyografya
Asıl Yazarlar: Buvoli, Massimo, Buvoli, Ada, Leinwand, Leslie A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2000
Konular:
Gene Expression
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC85606/
https://ncbi.nlm.nih.gov/pubmed/10757796
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