Suppression of Nonsense Mutations in Cell Culture and Mice by Multimerized Suppressor tRNA Genes

We demonstrate here the first experimental suppression of a premature termination codon in vivo by using an ochre suppressor tRNA acting in an intact mouse. Multicopy tRNA expression plasmids were directly injected into skeletal muscle and into the hearts of transgenic mice carrying a reporter gene...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Buvoli, Massimo, Buvoli, Ada, Leinwand, Leslie A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	Gene Expression
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85606/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10757796/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.9.3116-3124.2000
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