Mechanism of Suppression of the Raf/MEK/Extracellular Signal-Regulated Kinase Pathway by the Raf Kinase Inhibitor Protein

We have recently identified the Raf kinase inhibitor protein (RKIP) as a physiological endogenous inhibitor of the Raf-1/MEK/extracellular signal-regulated kinase (ERK) pathway. RKIP interfered with MEK phosphorylation and activation by Raf-1, resulting in the suppression of both Raf-1-induced trans...

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Bibliographische Detailangaben
Hauptverfasser: Yeung, Kam, Janosch, Petra, McFerran, Brian, Rose, David W., Mischak, Harald, Sedivy, John M., Kolch, Walter
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2000
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC85596/
https://ncbi.nlm.nih.gov/pubmed/10757792
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