Mechanism of Suppression of the Raf/MEK/Extracellular Signal-Regulated Kinase Pathway by the Raf Kinase Inhibitor Protein

We have recently identified the Raf kinase inhibitor protein (RKIP) as a physiological endogenous inhibitor of the Raf-1/MEK/extracellular signal-regulated kinase (ERK) pathway. RKIP interfered with MEK phosphorylation and activation by Raf-1, resulting in the suppression of both Raf-1-induced trans...

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में प्रकाशित:	Mol Cell Biol
मुख्य लेखकों:	Yeung, Kam, Janosch, Petra, McFerran, Brian, Rose, David W., Mischak, Harald, Sedivy, John M., Kolch, Walter
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	Taylor & Francis 2000
विषय:	Cell Growth and Development
ऑनलाइन पहुंच:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC85596/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10757792/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.9.3079-3085.2000
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