Role of Genotypic Analysis of the Thymidine Kinase Gene of Herpes Simplex Virus for Determination of Neurovirulence and Resistance to Acyclovir

Mutations in the thymidine kinase (TK) gene of herpes simplex virus (HSV) have been associated with resistance to acyclovir (ACY) and possible recognition of neurotropic strains. We sequenced a 335-bp segment of the TK gene to determine the frequency of mutations in HSV strains recovered from dermal...

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Main Authors: Lee, N. Y., Tang, Y.-W., Espy, M. J., Kolbert, C. P., Rys, P. N., Mitchell, P. S., Day, S. P., Henry, S. L., Persing, D. H., Smith, T. F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 1999
Fag:
Virology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC85520/
https://ncbi.nlm.nih.gov/pubmed/10488172
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