Posttranslational Modifications of p53 in Replicative Senescence Overlapping but Distinct from Those Induced by DNA Damage

Replicative senescence in human fibroblasts is absolutely dependent on the function of the phosphoprotein p53 and correlates with activation of p53-dependent transcription. However, no evidence for posttranslational modification of p53 in senescence has been presented, raising the possibility that c...

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Bibliographic Details
Main Authors: Webley, Katherine, Bond, Jane A., Jones, Christopher J., Blaydes, Jeremy P., Craig, Ashley, Hupp, Ted, Wynford-Thomas, David
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC85496/
https://ncbi.nlm.nih.gov/pubmed/10733583
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