Defects in tRNA Processing and Nuclear Export Induce GCN4 Translation Independently of Phosphorylation of the α Subunit of Eukaryotic Translation Initiation Factor 2

Induction of GCN4 translation in amino acid-starved cells involves the inhibition of initiator tRNA(Met) binding to eukaryotic translation initiation factor 2 (eIF2) in response to eIF2 phosphorylation by protein kinase GCN2. It was shown previously that GCN4 translation could be induced independent...

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Bibliographische Detailangaben
Hauptverfasser: Qiu, Hongfang, Hu, Cuihua, Anderson, James, Björk, Glenn R., Sarkar, Srimonti, Hopper, Anita K., Hinnebusch, Alan G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2000
Schlagworte:
Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC85456/
https://ncbi.nlm.nih.gov/pubmed/10713174
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