Calcium Depletion Dissociates and Activates Heterodimeric Notch Receptors

Notch receptors participate in a highly conserved signaling pathway that regulates morphogenesis in multicellular animals. Maturation of Notch receptors requires the proteolytic cleavage of a single precursor polypeptide to produce a heterodimer composed of a ligand-binding extracellular domain (N(E...

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Autors principals: Rand, Matthew D., Grimm, Lisa M., Artavanis-Tsakonas, Spyros, Patriub, Vytas, Blacklow, Stephen C., Sklar, Jeffrey, Aster, Jon C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2000
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC85363/
https://ncbi.nlm.nih.gov/pubmed/10669757
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