Inhibition of c-Jun N-Terminal Kinase 2 Expression Suppresses Growth and Induces Apoptosis of Human Tumor Cells in a p53-Dependent Manner

c-Jun N-terminal kinase (JNK) plays a critical role in coordinating the cellular response to stress and has been implicated in regulating cell growth and transformation. To investigate the growth-regulatory functions of JNK1 and JNK2, we used specific antisense oligonucleotides (AS) to inhibit their...

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Detalhes bibliográficos
Principais autores: Potapova, Olga, Gorospe, Myriam, Dougherty, Ryan H., Dean, Nicholas M., Gaarde, William A., Holbrook, Nikki J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC85354/
https://ncbi.nlm.nih.gov/pubmed/10669748
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