The Homeodomain of PDX-1 Mediates Multiple Protein-Protein Interactions in the Formation of a Transcriptional Activation Complex on the Insulin Promoter

Activation of insulin gene transcription specifically in the pancreatic β cells depends on multiple nuclear proteins that interact with each other and with sequences on the insulin gene promoter to build a transcriptional activation complex. The homeodomain protein PDX-1 exemplifies such interaction...

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Main Authors: Ohneda, Kinuko, Mirmira, Raghavendra G., Wang, Juehu, Johnson, Jeffrey D., German, Michael S.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Transcriptional Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC85207/
https://ncbi.nlm.nih.gov/pubmed/10629047
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