Modulated Binding of SATB1, a Matrix Attachment Region Protein, to the AT-Rich Sequence Flanking the Major Breakpoint Region of BCL2

The t(14,18) chromosomal translocation that occurs in human follicular lymphoma constitutively activates the BCL2 gene and disrupts control of apoptosis. Interestingly, 70% of the t(14,18) translocations are confined to three 15-bp clusters positioned within a 150-bp region (major breakpoint region...

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Main Authors: Ramakrishnan, Meera, Liu, Wen-Man, DiCroce, Patricia A., Posner, Aleza, Zheng, Jian, Kohwi-Shigematsu, Terumi, Krontiris, Theodore G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC85203/
https://ncbi.nlm.nih.gov/pubmed/10629043
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