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p53 Mutants Have Selective Dominant-Negative Effects on Apoptosis but Not Growth Arrest in Human Cancer Cell Lines

A bidirectional expression vector that allowed equal transcription of cloned wild-type and mutant p53 cDNAs from the same vector was developed. The vector was transfected into CaLu 6 lung carcinoma cells or Saos-2 osteosarcoma cells. All p53 mutants examined were recessive to wild-type p53 transacti...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Aurelio, Oscar N., Kong, Xiao-Tang, Gupta, Swati, Stanbridge, Eric J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2000
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC85193/
https://ncbi.nlm.nih.gov/pubmed/10629033
Tagiau: Ychwanegu Tag
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