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Stimulation of p53 DNA Binding by c-Abl Requires the p53 C Terminus and Tetramerization

The carboxyl terminus of p53 is a target of a variety of signals for regulation of p53 DNA binding. Growth suppressor c-Abl interacts with p53 in response to DNA damage and overexpression of c-Abl leads to G(1) growth arrest in a p53-dependent manner. Here, we show that c-Abl binds directly to the c...

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Bibliografiske detaljer
Main Authors: Nie, Ying, Li, Heng-Hong, Bula, Craig M., Liu, Xuan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC85189/
https://ncbi.nlm.nih.gov/pubmed/10629029
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