Cyclin D1 Is Required for Transformation by Activated Neu and Is Induced through an E2F-Dependent Signaling Pathway

The neu (c-erbB-2) proto-oncogene encodes a tyrosine kinase receptor that is overexpressed in 20 to 30% of human breast tumors. Herein, cyclin D1 protein levels were increased in mammary tumors induced by overexpression of wild-type Neu or activating mutants of Neu in transgenic mice and in MCF7 cel...

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Bibliographische Detailangaben
Hauptverfasser: Lee, Richard J., Albanese, Chris, Fu, Maofu, D'Amico, Mark, Lin, Bing, Watanabe, Genichi, Haines, George K., Siegel, Peter M., Hung, Mien-Chie, Yarden, Yosef, Horowitz, Jonathan M., Muller, William J., Pestell, Richard G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2000
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC85165/
https://ncbi.nlm.nih.gov/pubmed/10611246
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