Eukaryotic Translation Initiation Factor 4E (eIF4E) Binding Site and the Middle One-Third of eIF4GI Constitute the Core Domain for Cap-Dependent Translation, and the C-Terminal One-Third Functions as a Modulatory Region

The mammalian eukaryotic initiation factor 4GI (eIF4GI) may be divided into three roughly equal regions; an amino-terminal one-third (amino acids [aa] 1 to 634), which contains the poly(A) binding protein (PABP) and eIF4E binding sites; a middle third (aa 635 to 1039), which binds eIF4A and eIF3; an...

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Bibliographic Details
Main Authors: Morino, Shigenobu, Imataka, Hiroaki, Svitkin, Yuri V., Pestova, Tatyana V., Sonenberg, Nahum
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC85104/
https://ncbi.nlm.nih.gov/pubmed/10611225
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