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Biochemical Analysis of Distinct Activation Functions in p300 That Enhance Transcription Initiation with Chromatin Templates

To investigate the mechanisms of transcriptional enhancement by the p300 coactivator, we analyzed wild-type and mutant versions of p300 with a chromatin transcription system in vitro. Estrogen receptor, NF-κB p65 plus Sp1, and Gal4-VP16 were used as different sequence-specific activators. The CH3 do...

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Main Authors: Kraus, W. Lee, Manning, E. Tory, Kadonaga, James T.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 1999
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC84897/
https://ncbi.nlm.nih.gov/pubmed/10567538
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