Multiple Cbfa/AML Sites in the Rat Osteocalcin Promoter Are Required for Basal and Vitamin D-Responsive Transcription and Contribute to Chromatin Organization

Three Cbfa motifs are strategically positioned in the bone-specific rat osteocalcin (rOC) promoter. Sites A and B flank the vitamin D response element in the distal promoter and sites B and C flank a positioned nucleosome in the proximal promoter. The functional significance of each Cbfa element was...

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Main Authors: Javed, Amjad, Gutierrez, Soraya, Montecino, Martin, van Wijnen, André J., Stein, Janet L., Stein, Gary S., Lian, Jane B.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1999
Teme:
Transcriptional Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC84749/
https://ncbi.nlm.nih.gov/pubmed/10523637
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