The RAG1 Homeodomain Recruits HMG1 and HMG2 To Facilitate Recombination Signal Sequence Binding and To Enhance the Intrinsic DNA-Bending Activity of RAG1-RAG2

V(D)J recombination is initiated by the specific binding of the RAG1-RAG2 (RAG1/2) complex to the heptamer-nonamer recombination signal sequences (RSS). Several steps of the V(D)J recombination reaction can be reconstituted in vitro with only RAG1/2 plus the high-mobility-group protein HMG1 or HMG2....

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Aidinis, Vassilis, Bonaldi, Tiziana, Beltrame, Monica, Santagata, Sandro, Bianchi, Marco E., Spanopoulou, Eugenia
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 1999
Sujets:	DNA Dynamics and Chromosome Structure
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84623/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10490593/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.10.6532
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