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Evaluating Group I Intron Catalytic Efficiency in Mammalian Cells

Recent reports have demonstrated that the group I ribozyme from Tetrahymena thermophila can perform trans-splicing reactions to repair mutant RNAs. For therapeutic use, such ribozymes must function efficiently when transcribed from genes delivered to human cells, yet it is unclear how group I splici...

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Detalhes bibliográficos
Main Authors: Long, Meredith B., Sullenger, Bruce A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC84618/
https://ncbi.nlm.nih.gov/pubmed/10490588
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