E2F1 Has Both Oncogenic and Tumor-Suppressive Properties in a Transgenic Model

Using a transgenic mouse model expressing the E2F1 gene under the control of a keratin 5 (K5) promoter, we previously demonstrated that increased E2F1 activity can promote tumorigenesis by cooperating with either a v-Ha-ras transgene to induce benign skin papillomas or p53 deficiency to induce spont...

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Hlavní autoři: Pierce, Angela M., Schneider-Broussard, Robin, Gimenez-Conti, Irma B., Russell, Jamie L., Conti, Claudio J., Johnson, David G.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 1999
Témata:
Cell Growth and Development
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC84610/
https://ncbi.nlm.nih.gov/pubmed/10454586
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