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Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53

The p16(INK4a)-cyclin D–retinoblastoma tumor suppressor pathway is disrupted in most human cancers, and it has been suggested that the subsequent release of E2F transcription factors from inhibitory complexes may be a key event in tumor development. We described recently the generation of transgenic...

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Hlavní autoři: Pierce, Angela M., Gimenez-Conti, Irma B., Schneider-Broussard, Robin, Martinez, Luis A., Conti, Claudio J., Johnson, David G.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 1998
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC21167/
https://ncbi.nlm.nih.gov/pubmed/9671769
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