Increased E2F1 activity induces skin tumors in mice heterozygous and nullizygous for p53
The p16(INK4a)-cyclin D–retinoblastoma tumor suppressor pathway is disrupted in most human cancers, and it has been suggested that the subsequent release of E2F transcription factors from inhibitory complexes may be a key event in tumor development. We described recently the generation of transgenic...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21167/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9671769/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.15.8858 |
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