Elevated Cyclin E Levels, Inactive Retinoblastoma Protein, and Suppression of the p27(KIP1) Inhibitor Characterize Early Development of Promyeloid Cells into Macrophages

Cyclin-dependent kinase inhibitors such as p27(KIP1) have recently been shown to lead to cellular differentiation by causing cell cycle arrest, but it is unknown whether similar events occur in differentiating promyeloid cells. Hematopoietic progenitor cells undergo lineage-restricted differentiatio...

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Autors principals: Liu, Qiang, VanHoy, Roger W., Zhou, J. H., Dantzer, Robert, Freund, Gregory G., Kelley, Keith W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1999
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC84572/
https://ncbi.nlm.nih.gov/pubmed/10454569
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