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Myc Downregulation by Transforming Growth Factor β Required for Activation of the p15(Ink4b) G(1) Arrest Pathway

The antimitogenic action of transforming growth factor β (TGF-β) in epithelial cells involves cyclin-dependent kinase (cdk) inhibitory gene responses and downregulation of c-Myc expression. Although the cdk inhibitory responses are sufficient for G(1) arrest, enforced expression of c-Myc prevents G(...

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Autors principals: Warner, Beverley J., Blain, Stacy W., Seoane, Joan, Massagué, Joan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC84444/
https://ncbi.nlm.nih.gov/pubmed/10454538
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