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Overproduction of Human Myt1 Kinase Induces a G(2) Cell Cycle Delay by Interfering with the Intracellular Trafficking of Cdc2-Cyclin B1 Complexes

The Myt1 protein kinase functions to negatively regulate Cdc2-cyclin B complexes by phosphorylating Cdc2 on threonine 14 and tyrosine 15. Throughout interphase, human Myt1 localizes to the endoplasmic reticulum and Golgi complex, whereas Cdc2-cyclin B1 complexes shuttle between the nucleus and the c...

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Publicat a:Mol Cell Biol
Autors principals: Liu, Feng, Rothblum-Oviatt, Cynthia, Ryan, Christine E., Piwnica-Worms, Helen
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis 1999
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84354/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10373560/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.7.5113
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