Induced Focal Adhesion Kinase (FAK) Expression in FAK-Null Cells Enhances Cell Spreading and Migration Requiring Both Auto- and Activation Loop Phosphorylation Sites and Inhibits Adhesion-Dependent Tyrosine Phosphorylation of Pyk2

Focal adhesion kinase (FAK) is a nonreceptor protein tyrosine kinase involved in integrin-mediated control of cell behavior. Following cell adhesion to components of the extracellular matrix, FAK becomes phosphorylated at multiple sites, including tyrosines 397, 576, and 577. Tyr-397 is an autophosp...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Owen, James D., Ruest, Paul J., Fry, David W., Hanks, Steven K.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1999
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84279/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10373530/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.7.4806
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