Extracellular Signal-Regulated Kinase Activates Topoisomerase IIα through a Mechanism Independent of Phosphorylation

The mitogen-activated protein (MAP) kinases, extracellular signal-related kinase 1 (ERK1) and ERK2, regulate cellular responses by mediating extracellular growth signals toward cytoplasmic and nuclear targets. A potential target for ERK is topoisomerase IIα, which becomes highly phosphorylated durin...

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Autors principals: Shapiro, Paul S., Whalen, Anne M., Tolwinski, Nicholas S., Wilsbacher, Julie, Froelich-Ammon, Stacie J., Garcia, Marileila, Osheroff, Neil, Ahn, Natalie G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1999
Matèries:
Cell Growth and Development
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC84147/
https://ncbi.nlm.nih.gov/pubmed/10207078
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