Reactivation of Mutant p53 through Interaction of a C-Terminal Peptide with the Core Domain

A synthetic 22-mer peptide (peptide 46) derived from the p53 C-terminal domain can restore the growth suppressor function of mutant p53 proteins in human tumor cells (G. Selivanova et al., Nat. Med. 3:632–638, 1997). Here we demonstrate that peptide 46 binds mutant p53. Peptide 46 binding sites were...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Selivanova, Galina, Ryabchenko, Ludmila, Jansson, Emmelie, Iotsova, Violetta, Wiman, Klas G.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1999
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84132/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10207063/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.5.3395
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