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Allosteric Regulation of the Discriminative Responsiveness of Retinoic Acid Receptor to Natural and Synthetic Ligands by Retinoid X Receptor and DNA

Transcriptional activation by retinoids is mediated through two families of nuclear receptors, all-trans-retinoic acid (RARs) and 9-cis retinoic acid receptors (RXRs). Conformationally restricted retinoids are used to achieve selective activation of RAR isotype α, β or γ, which reduces side effects...

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Autori principali: Mouchon, Arnaud, Delmotte, Marie-Hélène, Formstecher, Pierre, Lefebvre, Philippe
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 1999
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC84101/
https://ncbi.nlm.nih.gov/pubmed/10082574
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