Polypyrimidine Tract Binding Protein Functions as a Repressor To Regulate Alternative Splicing of α-Actinin Mutally Exclusive Exons

The smooth muscle (SM) and nonmuscle (NM) isoforms of α-actinin are produced by mutually exclusive splicing of an upstream NM exon and a downstream SM-specific exon. A rat α-actinin genomic clone encompassing the mutually exclusive exons was isolated and sequenced. The SM exon was found to utilize t...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Southby, Justine, Gooding, Clare, Smith, Christopher W. J.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 1999
Sujets:
Gene Expression
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC84063/
https://ncbi.nlm.nih.gov/pubmed/10082536
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