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Polypyrimidine Tract Binding Protein Functions as a Repressor To Regulate Alternative Splicing of α-Actinin Mutally Exclusive Exons

The smooth muscle (SM) and nonmuscle (NM) isoforms of α-actinin are produced by mutually exclusive splicing of an upstream NM exon and a downstream SM-specific exon. A rat α-actinin genomic clone encompassing the mutually exclusive exons was isolated and sequenced. The SM exon was found to utilize t...

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Udgivet i:Mol Cell Biol
Principais autores: Southby, Justine, Gooding, Clare, Smith, Christopher W. J.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 1999
Fag:
Gene Expression
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84063/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10082536/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.4.2699
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