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The Highly Conserved β-Hairpin of the Paired DNA-Binding Domain Is Required for Assembly of Pax-Ets Ternary Complexes

Pax family transcription factors bind DNA through the paired domain. This domain, which is comprised of two helix-turn-helix motifs and a β-hairpin structure, is a target of mutations in congenital disorders of mice and humans. Previously, we showed that Pax-5 (B-cell-specific activator protein) rec...

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Publicado no:Mol Cell Biol
Principais autores: Wheat, William, Fitzsimmons, Daniel, Lennox, Heidi, Krautkramer, Susan R., Gentile, Lisa N., McIntosh, Lawrence P., Hagman, James
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 1999
Assuntos:
Transcriptional Regulation
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84016/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10022910/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.3.2231
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