A Novel Genetic Screen for snRNP Assembly Factors in Yeast Identifies a Conserved Protein, Sad1p, Also Required for Pre-mRNA Splicing

The assembly pathway of spliceosomal snRNPs in yeast is poorly understood. We devised a screen to identify mutations blocking the assembly of newly synthesized U4 snRNA into a functional snRNP. Fifteen mutant strains failing either to accumulate the newly synthesized U4 snRNA or to assemble a U4/U6...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Lygerou, Zoi, Christophides, George, Séraphin, Bertrand
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 1999
Soggetti:	Gene Expression
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC83994/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10022888/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.3.2008
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