A Novel Genetic Screen for snRNP Assembly Factors in Yeast Identifies a Conserved Protein, Sad1p, Also Required for Pre-mRNA Splicing

The assembly pathway of spliceosomal snRNPs in yeast is poorly understood. We devised a screen to identify mutations blocking the assembly of newly synthesized U4 snRNA into a functional snRNP. Fifteen mutant strains failing either to accumulate the newly synthesized U4 snRNA or to assemble a U4/U6...

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Main Authors: Lygerou, Zoi, Christophides, George, Séraphin, Bertrand
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 1999
Ábhair:
Gene Expression
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC83994/
https://ncbi.nlm.nih.gov/pubmed/10022888
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