Activation of Transcription by Metabolic Intermediates of the Pyrimidine Biosynthetic Pathway

Saccharomyces cerevisiae responds to pyrimidine starvation by increasing the expression of four URA genes, encoding the enzymes of de novo pyrimidine biosynthesis, three- to eightfold. The increase in gene expression is dependent on a transcriptional activator protein, Ppr1p. Here, we investigate th...

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Bibliographic Details
Main Authors: Flynn, Paul J., Reece, Richard J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Transcriptional Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC83945/
https://ncbi.nlm.nih.gov/pubmed/9858611
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