Regulation of the mdm2 Oncogene by Thyroid Hormone Receptor
The mdm2 gene is positively regulated by p53 through a p53-responsive DNA element in the first intron of the mdm2 gene. mdm2 binds p53, thereby abrogating the ability of p53 to activate the mdm2 gene, and thus forming an autoregulatory loop of mdm2 gene regulation. Although the mdm2 gene is thought...
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| Veröffentlicht in: | Mol Cell Biol |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
1999
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC83943/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9858609/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.1.864 |
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