Regulation of the mdm2 Oncogene by Thyroid Hormone Receptor

The mdm2 gene is positively regulated by p53 through a p53-responsive DNA element in the first intron of the mdm2 gene. mdm2 binds p53, thereby abrogating the ability of p53 to activate the mdm2 gene, and thus forming an autoregulatory loop of mdm2 gene regulation. Although the mdm2 gene is thought...

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Hlavní autoři: Qi, Jian-Shen, Yuan, Yaping, Desai-Yajnik, Vandana, Samuels, Herbert H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 1999
Témata:
Transcriptional Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC83943/
https://ncbi.nlm.nih.gov/pubmed/9858609
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