Ribosomal Pausing and Scanning Arrest as Mechanisms of Translational Regulation from Cap-Distal Iron-Responsive Elements

Iron regulatory protein 1 (IRP-1) binding to an iron-responsive element (IRE) located close to the cap structure of mRNAs represses translation by precluding the recruitment of the small ribosomal subunit to these mRNAs. This mechanism is position dependent; reporter mRNAs bearing IREs located furth...

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Autori principali: Paraskeva, Efrosyni, Gray, Nicola K., Schläger, Britta, Wehr, Kristina, Hentze, Matthias W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 1999
Soggetti:
Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC83937/
https://ncbi.nlm.nih.gov/pubmed/9858603
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