CREB Binding Protein Interacts with Nucleoporin-Specific FG Repeats That Activate Transcription and Mediate NUP98-HOXA9 Oncogenicity

Genes encoding the Phe-Gly (FG) repeat-containing nucleoporins NUP98 and CAN/NUP214 are at the breakpoints of several chromosomal translocations associated with human acute myeloid leukemia (AML), but their role in oncogenesis is unclear. Here we demonstrate that the NUP98-HOXA9 fusion gene encodes...

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Auteurs principaux: Kasper, Lawryn H., Brindle, Paul K., Schnabel, Catherine A., Pritchard, Colin E. J., Cleary, Michael L., van Deursen, Jan M. A.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 1999
Sujets:
Cell Growth and Development
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC83933/
https://ncbi.nlm.nih.gov/pubmed/9858599
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