Hydroxycarbamide effects on DNA methylation and gene expression in myeloproliferative neoplasms

Hydroxycarbamide (HC, hydroxyurea) is a cytoreductive drug inducing cell cycle blockade. However, emerging evidence suggests that HC plays a role in the modulation of transcription through the activity of transcription factors and DNA methylation. Examining the global mechanism of action of HC in th...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Genome Res
Autori principali: Contreras Castillo, Stephania, Montibus, Bertille, Rocha, Azucena, Duke, Will, von Meyenn, Ferdinand, McLornan, Donal, Harrison, Claire, Mullally, Ann, Schulz, Reiner, Oakey, Rebecca J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2021
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8327916/
https://ncbi.nlm.nih.gov/pubmed/34244229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.270066.120
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