Intratumoral talimogene laherparepvec injection with concurrent preoperative radiation in patients with locally advanced soft-tissue sarcoma of the trunk and extremities: phase IB/II trial

BACKGROUND: Soft-tissue sarcomas (STS) in the extremities and trunk treated with standard-of-care preoperative external beam radiation therapy (EBRT) followed by surgical resection are associated with local and distant relapses. In preclinical studies, oncolytic virotherapy in sarcoma has demonstrat...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Monga, Varun, Miller, Benjamin J, Tanas, Munir, Boukhar, Sarag, Allen, Bryan, Anderson, Carryn, Stephens, Laura, Hartwig, Stacey, Varga, Steven, Houtman, Jon, Wang, Lei, Zhang, Weizhou, Jaber, Omar, Thomason, Jon, Kuehn, David, Rajput, Maheen, Metz, Catherine, Zamba, K.D., Mott, Sarah, Abanonu, Chinemerem, Bhatia, Sudershan, Milhem, Mohammed
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2021
Assuntos:
Oncolytic and Local Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8327848/
https://ncbi.nlm.nih.gov/pubmed/34330766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2021-003119
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