Regulation of a pentameric ligand-gated ion channel by a semiconserved cationic lipid-binding site

Pentameric ligand-gated ion channels (pLGICs) are crucial mediators of electrochemical signal transduction in various organisms from bacteria to humans. Lipids play an important role in regulating pLGIC function, yet the structural bases for specific pLGIC-lipid interactions remain poorly understood...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Sridhar, Akshay, Lummis, Sarah C.R., Pasini, Diletta, Mehregan, Aujan, Brams, Marijke, Kambara, Kumiko, Bertrand, Daniel, Lindahl, Erik, Howard, Rebecca J., Ulens, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8327344/
https://ncbi.nlm.nih.gov/pubmed/34157288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100899
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