Metabolomic and transcriptional profiling reveals bioenergetic stress and activation of cell death and inflammatory pathways in vivo after neuronal deletion of NAMPT

Nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the NAD(+) salvage pathway. Our previous study demonstrated that deletion of NAMPT gene in projection neurons using Thy1-NAMPT(−/−) conditional knockout (cKO) mice causes neuronal degeneration, muscle atrophy, neuromuscula...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Lundt, Samuel, Zhang, Nannan, Li, Jun-Liszt, Zhang, Zhe, Zhang, Li, Wang, Xiaowan, Bao, Ruisi, Cai, Feng, Sun, Wenzhi, Ge, Woo-Ping, Ding, Shinghua
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2021
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8327099/
https://ncbi.nlm.nih.gov/pubmed/33563078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X21992625
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