The cross-talk between tumor cells and activated fibroblasts mediated by lactate/BDNF/TrkB signaling promotes acquired resistance to anlotinib in human gastric cancer

Acquired resistance to tyrosine kinase inhibitors (TKIs) is the major obstacle to improve clinical efficacy in cancer patients. The epithelial-stromal interaction in tumor microenvironment influences cancer drug response to TKIs. Anlotinib is a novel oral multi-targeted TKI, and has recently been pr...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Jin, Zhijian, Lu, Yifan, Wu, Xiongyan, Pan, Tao, Yu, Zhenjia, Hou, Junyi, Wu, Airong, Li, Jianfang, Yang, Zhongyin, Li, Chen, Yan, Min, Yan, Chao, Zhu, Zhenggang, Liu, Bingya, Qiu, Weihua, Su, Liping
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8326414/
https://ncbi.nlm.nih.gov/pubmed/34315112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2021.102076
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