Transcriptional regulation of CYP19 by cohesin-mediated chromosome tethering in human granulosa cells

Human CYP19 spans a region of chromosome 15 of approximately 130 kb and encodes aromatase, an enzyme required for estrogen synthesis. In the human granulosa cell-line KGN, there are seven open chromatin regions within the CYP19 locus. In this study, we demonstrate that two of these regions ~40 kb up...

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Bibliografische gegevens
Gepubliceerd in:Biochem Biophys Rep
Hoofdauteurs: Kotomura, Naoe, Harada, Nobuhiro, Shimono, Yohei, Ishihara, Satoru
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2021
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Short Communication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8326343/
https://ncbi.nlm.nih.gov/pubmed/34368471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2021.101086
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